Once-weekly REZZAYO® (rezafungin for injection) may simplify your invasive candidiasis infusion treatment

What is REZZAYO®?

REZZAYO® is an antifungal medication used to treat candidemia and invasive candidiasis, which are infections in the bloodstream or internal organs caused by a yeast (fungus) called Candida.

REZZAYO® is approved for adults 18 years of age or older who have limited or no alternative options for the treatment of candidemia and invasive candidiasis. FDA approval of REZZAYO® was based on limited clinical safety and effectiveness data. REZZAYO® has not been studied in patients with Candida infections of the heart (endocarditis), bone (osteomyelitis), or brain and spinal cord (meningitis).

IMPORTANT SAFETY INFORMATION

Do not take REZZAYO® if you are allergic to rezafungin or other echinocandins.

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Simplify your treatment with once-weekly REZZAYO®

There are many other echinocandin infusion treatments you may have heard of, such as caspofungin, micafungin, and anidulafungin, but REZZAYO® is different because it is dosed once-weekly.

In clinical trials with over 200 adults with candidemia and invasive candidiasis, once-weekly REZZAYO® was shown to be as effective as a daily infusion of caspofungin.

The most common side effects of REZZAYO® are fever, diarrhea, anemia, vomiting, nausea, stomach pain, constipation, and low levels of potassium, magnesium, or phosphate in the blood. Please see Important Safety Information below and full Prescribing Information.

As you can see in the chart below, with REZZAYO®, an infusion is needed only once a week—rather than daily—making it easier to fit into your schedule.

Once-weekly
REZZAYO
®
Week 1

Day 1: 400-mg loading dose

Week 2

Day 8: 200-mg weekly dose

No PICC
required*

VS

Daily IV
echinocandin

Day 1

Day 2

Day 3

Day 4

Day 5

Day 6

Day 7

Day 1

Day 2

Day 3

Day 4

Day 5

Day 6

Day 7

Daily PICC
maintenance
to prevent
infection

*Unlike daily IV antifungal treatment, REZZAYO® does not require what is called a central IV line (often referred to as a PICC line), which is a long, thin tube that must be inserted into the arm for an extended period of time in order to administer the drug.

If you’ve been prescribed a daily antifungal infusion, such as caspofungin, micafungin, or anidulafungin, there are a few questions you may want to ask your healthcare team:

Q:

Are there other treatment options that don’t need to be taken so often?

Q:

Can I avoid
a PICC line?

Q:

Do I have to go to
an infusion center every day?

Here are a few reasons why you may want to talk to your healthcare team about once-weekly REZZAYO®:

One IV infusion once a week for 1 hour

REZZAYO® can be given at the hospital, at an infusion center, or at home by a nurse

REZZAYO® does not require a central IV line or PICC*

Copay assistance may be available for eligible patients with private commercial insurance—ask your healthcare team for information

REZZAYO® can be taken safely with other commonly prescribed medications

Once-weekly REZZAYO® is the first FDA-approved treatment of its kind in over 15 years

*Unlike daily IV antifungal treatment, REZZAYO® does not require what is called a central IV line (often referred to as a PICC line), which is a long, thin tube that must be inserted into the arm for an extended period of time in order to administer the drug.

A patient will not qualify if they have a prescription drug benefit through a government program (ie, Medicaid, Medicare, Medicare Part D, Medigap, CHAMPUS, DOD, VA, TRICARE, or any state patient or pharmaceutical assistance program).

As a condition for receiving copays or coinsurance, both healthcare professionals and patients are required to inform patients’ insurance companies and third-party payers of any copays or coinsurance benefits paid by this program.

Void where prohibited by law, taxed, or restricted. Additional terms and conditions may apply. Patients enrolled in the REZZAYO® Patient Assistance Program are not eligible. Melinta Therapeutics, LLC may determine eligibility, monitor participation, and modify or discontinue any aspect of this program at any time.

icon medical dropper

Talk to your healthcare team today about once-weekly REZZAYO® to see if it’s right for you

Actor Portrayal

What is REZZAYO®?

REZZAYO® is an antifungal medication used to treat candidemia and invasive candidiasis, which are infections in the bloodstream or internal organs caused by a yeast (fungus) called Candida.

REZZAYO® is approved for adults 18 years of age or older who have limited or no alternative options for the treatment of candidemia and invasive candidiasis. FDA approval of REZZAYO® was based on limited clinical safety and effectiveness data. REZZAYO® has not been studied in patients with Candida infections of the heart (endocarditis), bone (osteomyelitis), or brain and spinal cord (meningitis).

IMPORTANT SAFETY INFORMATION

Do not take REZZAYO® if you are allergic to rezafungin or other echinocandins.

Before you take REZZAYO®, tell your doctor about all your medical conditions, including if you are allergic to rezafungin or other echinocandins, have liver problems or have had abnormal liver tests, have ever had a reaction to an IV infusion, spend a lot of time in the sun or use tannings beds, are pregnant or plan to become pregnant (it is not known if REZZAYO® can harm your unborn baby; talk to your doctor if you are pregnant or plan to become pregnant), are breastfeeding or plan to breastfeed (it is not known if REZZAYO® passes into breast milk; talk to your doctor about the best way to feed your baby if you take REZZAYO®).

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What are the possible side effects of REZZAYO®?

REZZAYO® may cause serious side effects including:

  • Allergic Reactions, Including Severe Reactions (Anaphylaxis): REZZAYO® may cause allergic reactions, including anaphylaxis. Symptoms can include difficulty breathing, swelling of the lips, face, tongue, or throat, hives or rash, or feeling faint. These reactions may be life-threatening. Stop using REZZAYO® and get emergency medical help right away if you have allergic reactions symptoms or trouble breathing.
  • Infusion-related Reactions: You may experience certain reactions when you are receiving REZZAYO® through the IV, including flushing, warm sensations, hives, nausea, or tightness in the chest. If these reactions occur, tell your doctor right away. They may slow or stop the infusion.
  • Photosensitivity: REZZAYO® may cause you to be more sensitive to sunlight. While taking REZZAYO®, protect yourself from the sun and other sources of ultraviolet (UV) light by using sunscreen, wearing protective clothing, and avoiding tanning beds.
  • Liver-related Side Effects: In the clinical trials for REZZAYO®, some patients had abnormal liver test results. Your doctor will monitor you closely if you have abnormal liver test results and decide whether you should keep taking REZZAYO®.

The most common side effects of REZZAYO® are low levels of potassium, fever, diarrhea, anemia, vomiting, nausea, low levels of magnesium, stomach pain, constipation and low levels of phosphate.

These are not all the possible side effects of REZZAYO®. For more information, ask your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information.

Important Safety Information  
What is REZZAYO®?

REZZAYO® is an antifungal medication used to treat candidemia and invasive candidiasis, which are infections in the bloodstream or internal organs caused by a yeast (fungus) called Candida.

IMPORTANT SAFETY INFORMATION

Do not take REZZAYO® if you are allergic to rezafungin or other echinocandins.